MyBioSource.com's NLRP6 Antibody (N-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The NLRP6 Antibody (N-term) was generated using AVR, NALP6, and NLRP6 as the antigen and it reacts with Human.
Description
NALPs are cytoplasmic proteins that form a subfamily
within the larger CATERPILLER protein family. Most short NALPs,
such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain
(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),
and a C-terminal leucine-rich repeat (LRR) region. The long NALP,
NALP1 (MIM 606636), also has a C-terminal extension containing a
function to find domain (FIIND) and a caspase recruitment domain
(CARD). NALPs are implicated in the activation of proinflammatory
caspases (e.g., CASP1; MIM 147678) via their involvement in
multiprotein complexes called inflammasomes (Tschopp et al., 2003
[PubMed 12563287])